General Hospital spoilers for October 22, 2025, tease a thrilling day in Port Charles. Carly Spencer takes a dangerous leap toward revenge while Nathan West endures intense WSB questioning. Meanwhile, Britt Westbourne clashes with Anna Devane, and Sonny Corinthos faces an unexpected visitor who could change everything.
Carly Plots Revenge With a Dangerous Alliance
General Hospital spoilers for October 22, 2025, reveal Carly Spencer diving headfirst into dangerous territory. Determined to take Jack Brennan down, she puts her disguise to good use and heads straight for Valentin Cassadine’s cell. Their meeting could change everything for Port Charles.
Carly’s vengeance burns stronger than ever after Brennan’s betrayal. She believes Valentin might still want payback too, and she’s ready to join forces. However, trust is a fragile thing in Port Charles. Carly’s move could either bring Brennan’s downfall or unleash chaos she can’t control.
General Hospital Spoilers: Nathan Faces WSB Pressure Over His Past
Meanwhile, Nathan West’s world spins out of control as the WSB turns up the heat. Jack Brennan drags him into an intense interrogation, determined to uncover the truth about Nathan’s missing years. He even shows him pre-crash footage to jog his memory.
Nathan insists he remembers nothing about his time before the accident. But Brennan isn’t convinced. He suspects Nathan’s connection to Cesar Faison’s final project runs deeper than anyone knows. Nathan’s blank memory could be his greatest weakness—or the very thing keeping him safe.
Britt & Anna Clash Over Hidden Truths
Elsewhere, Britt Westbourne faces off with Anna Devane once again. Anna believes Britt has ties to Faison’s final experiment, and she’s determined to get answers. But Britt’s denial and sarcasm only make Anna more suspicious.
Anna may even push Britt to reveal what she knows about Nathan’s return. Yet Britt won’t fold easily. Her secrets could unravel everything Anna’s been working toward—and put Nathan in greater danger than ever before.
General Hospital Spoilers: Quartermaine Tensions Boil Over
At the Quartermaine mansion, family drama brews as Tracy clashes with Lulu Spencer. Tracy’s paranoia about Ronnie Bard continues to grow. Lulu, however, believes Tracy is overreacting. Still, Tracy’s gut tells her Ronnie’s hiding something big.
Meanwhile, Gio Palmieri teams up with Emma Scorpio-Drake, plotting their next move amid the Quartermaine chaos. Their schemes could tie back to Professor Hank Dalton—or perhaps stir even more trouble for the already feuding family.
Sonny’s Unexpected Visitor Shakes Things Up
Over at Sonny Corinthos’s home, Lois Cerullo makes a surprise appearance. She doesn’t waste time before teasing Sonny about whether he’ll invite her in or tell her to “kick rocks.” Sonny eventually lets her in, and they talk about Brook Lynn and Gio.
Their conversation could reveal new sides of Sonny’s softer nature—and hint at upcoming family turmoil. With everything heating up in Port Charles, Lois’s return might bring some much-needed clarity or stir new emotions Sonny isn’t ready to face.
General Hospital spoilers for October 22, 2025, promise explosive drama as Carly takes risks, Nathan faces his past, and Britt guards her truth. The web of lies is tightening fast, and one wrong move could expose everyone. Stay tuned for more at Soap Opera Daily—your home for all General Hospital drama!