The upcoming General Hospital update for September 22, 2025, promises heartbreak, tense confrontations, and an unfolding mystery. Monica’s death sends ripples through Port Charles, Nathan’s shocking reappearance raises urgent questions, and Lulu pushes Britt toward peace. With secrets unraveling, emotions will run dangerously high in every storyline.
Sonny and Carly Confront Grief Together
As Monica Quartermaine’s death becomes known, Sonny and Carly will lean on each other. They’ll revisit their past losses, acknowledging the pain never fades. Both will share concern for Jason and Michael, who remain deeply affected. Their quiet support will highlight the enduring strength of their bond.

At the Quartermaine mansion, Lucy will arrive unaware of Monica’s passing. She’ll come with her usual pitch, only to be cut short. Tracy, consumed with grief and frustration, will slam the door in Lucy’s face. The move will underline Tracy’s unwillingness to deal with distractions during this tragic moment.
General Hospital: Brook Lynn’s Confession and Cody’s Support
Brook Lynn will find comfort in Cody, though her thoughts will extend beyond Monica’s loss. She’ll open up about her uncertainty with Gio, reflecting on the fragile state of her relationship. Cody will listen closely, showing the depth of their growing friendship.

Meanwhile, Cody’s return to the stables could spark new changes. Brook Lynn may hint at rewriting the rules, potentially making space for Cody’s pup. This adjustment will serve as a symbolic step forward, as both characters attempt to navigate grief and life’s uncertainties together.
Molly Seeks Alexis’ Guidance
Molly will face her own personal dilemma as she admits her growing feelings for Cody. Confiding in Alexis, she’ll seek guidance on how to move forward. Alexis will offer wisdom, urging Molly to weigh her emotions carefully before taking action.

This mother-daughter moment will highlight Alexis’ steady influence. Molly’s vulnerable admission will also underscore how fragile relationships can feel during uncertain times. The advice she receives may play a significant role in shaping her next steps with Cody.
General Hospital: Nathan’s Mysterious Return Stuns Port Charles
At General Hospital, Anna will wrestle with a shocking discovery. An unconscious man, identical to Nathan, will be wheeled into the hospital. This revelation will ignite immediate speculation about his true identity. The possibility of Nathan’s return will stir fear, hope, and suspicion.

Anna, Dante, and Chase will join forces to investigate the truck accident that led to his arrival. With secrecy in mind, Anna will insist on keeping the matter contained. Lucas and Elizabeth will promise silence, though their doubts will remain unresolved. The uncertainty will leave everyone questioning reality.
Lulu and Britt’s Attempt at Peace
Elsewhere, Lulu will extend an olive branch to Britt. She’ll argue that Rocco deserves harmony, pushing for a truce. Though hesitant, Britt may agree, seeing the necessity of peace for Rocco’s sake.

Still, Britt’s world will soon be shaken further. Anna may question her directly, suspecting she knows more about Nathan’s sudden reappearance. With Faison’s shadow looming, Britt could face accusations that tie her to dangerous secrets. This uneasy truce may collapse under the weight of shocking revelations.
This General Hospital update for September 22, 2025, sets the stage for powerful emotions and escalating mysteries. From Monica’s devastating loss to Nathan’s shocking reappearance, Port Charles is bracing for dramatic changes. Stay tuned to Soap Opera Daily for every General Hospital update and unfolding twist.